Clinical Research
Revascularization is performed on pernament teeth that have become necrotic and infected and are immature.
In one study (Takushige T, eta!. Endodontic Treatment of Primary Teeth Using a Combination of Antibacterial Drugs. International) applied this theory clinically in a trial involving 87 infected primary molars. The results showed that 83 of the 87 cases demonstrated healing after one application of treatment. In those 83 cases, pain, swelling, and fistulas resolved within one week of the therapy. (Mean observation period - 680 days)
Contemp Clin Dent. 2010 Jan-Mar; 1(1): 31–35.
Sonali Taneja, Manju Kumari, and Hari Parkash1
The infection of the root canal system is considered to be a polymicrobial infection, consisting of both aerobic and anaerobic bacteria. Because of the complexity of the root canal infection, it is unlikely that any single antibiotic could result in effective sterilization of the canal. A combination of antibiotic drugs (metronidazole, ciprofloxacin, and minocycline) is used to eliminate target bacteria, which are possible sources of endodontic lesions. Three case reports describe the nonsurgical endodontic treatment of teeth with large periradicular lesions. A triple antibiotic paste was used for 3 months. After 3 months, teeth were asymptomatic and were obturated. The follow-up radiograph of all the three cases showed progressive healing of periradicular lesions. The results of these cases show that when most commonly used medicaments fail in eliminating the symptoms then a triple antibiotic paste can be used clinically in the treatment of teeth with large periradicular lesions.
J Endod. 2005 Jun;31(6):439-43.
Windley W 3rd, Teixeira F, Levin L, Sigurdsson A, Trope M.
This study assessed the efficacy of a triple antibiotic paste in the disinfection of immature dog teeth with apical periodontitis. The canals were sampled before (S1) and after (S2) irrigation with 1.25% NaOCL and after dressing with a triple antibiotic paste (S3), consisting of metronidazole, ciprofloxacin, and minocycline. At S1, 100% of the samples cultured positive for bacteria with a mean CFU count of 1.7 x 10. At S2, 10% of the samples cultured bacteria-free with a mean CFU count of 1.4 x 10. At S3, 70% of the samples cultured bacteria-free with a mean CFU count of only 26. Reductions in mean CFU counts between S1 and S2 (p < 0.0001) as well as between S2 and S3 (p < 0.0001) were statistically significant. These results indicate the effectiveness of a triple antibiotic paste in the disinfection of immature teeth with apical periodontitis.
Before using PulpVaz, please assess the patient for allergies to Ciprofloxacin, Metronidazole, Clindamycin, (iodine – on the PV3i form), and propylene glycol. *This has been added to the formula to allow the product to be radio opaque upon x-ray.
