HistoryTraditionally the treatment for teeth with infected root canals/periradicular tissue was extraction or endodontic pulpectomy therapy. These extractions may lead to undesirable tooth movements of primary and/or permanent teeth including loss of arch length.

Although the success rates of pulpectomies involving primary teeth are good, the technique can be very challenging due to the morphology of the canals. Research has shown that even after thorough mechanical and chemical cleaning of the canals, up to 40% of permanent teeth canals may still exhibit positive bacterial cultures, reducing long-term success rates of pulpectomies.

 The first article explaining the use of Metronidazole, Ciprofloxacin and Minocycline was by Hoshino et al (1).  Since then many endodontists have used the mixture with excellent results.  The problem with this original mixture is that the antibiotic, Minocycline, causes a discoloration of the tooth and gums.  To prevent this problem NuCara Pharmacy has replaced Minocycline with Clindamycin.

The other patent-pending improvement that NuCara Pharmacy made to the original 3-mix dental paste is to add an element that allows the endodontist or dentist to assure that the paste has been placed within 1-2 mm of the apex of the root by making the paste radiopaque.  An x-ray can be taken which will confirm that the canal has been completely filled with PulpVaz to ensure a bacteria-free canal with a reduced chance of re-infection.
Hoshino E, Kurihara-Ando N, Sato I, Uematsu H, Sato M, Kota K, Iwaku M. In vitro antibacterial susceptibility
of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline.  Int Endod J 1996: 29: 125–130.





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The information contained in this website is provided for educational purposes only and is not intended to replace discussions with your healthcare provider. All decisions regarding a patients' treatment must be made with a healthcare provider. PulpVAZ� and PulpHEALTM are available as a compounded medication exclusively from MedCara Pharmaceuticals and dispensed under an exclusive contract by NuCara Pharmacy. PulpVAZ and PulpHEAL as formulations have not been through FDA testing. PulpVAZ and PulpHEAL have been compounded under prescription from a licensed professional and is dispensed under a specific patient name. MedCara Pharmaceuticals and NuCara Pharmacy does not make any claims, overt or implied, of the safety or effectiveness of the PulpVAZ or PulpHEAL compounds. We refer only to references pertaining to peer reviewed medical publications and/or safety studies endorsed by the FDA. In keeping with FDA regulations, MedCara Pharmaceutical�s intentions are to provide pertinent and informative facts and information that will assist a person in making a well informed and educated decision about his/her medical care.
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